Abstract
Periaqueductal gray (PAG) is a well-documented region on integrated defensive responses and anxiety-like behavior. However, only recently has been shown its role in drug/alcohol consumption, mainly in the relapse state and associated with anxiety. NPY is known as the major anxiolytic endogen neuropeptide, besides its well-recognized orexigenic action mediated mainly by NPY-Y1 and NPY-Y5 receptors respectively. Herein, we addressed the role of the NPY-Y1 receptor in the dorsal (D)-PAG on anxiety-like behavior through a defensive burying test, as well as the food, sucrose, and alcohol consumption in male Wistar rats, with a sucrose fading paradigm at the juvenile stage as the alcohol intake initiation procedure. Present results confirmed that intra D-PAG NPY is a key modulator neurotransmitter system on anxiety-like behavior. Additionally, NPY significantly increased both the food and sucrose intake and decreased the alcohol consumption in voluntary sucrose (10%) and alcohol at different concentrations models. These results are likely mediated by NPY acting in the NPY-Y1 receptor in the D-PAG.
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