Abstract
WHEN oestradiol enters a responsive cell, it binds to a receptor protein and is transported into the nucleus where it is attached to chromatin1–3. The “acceptor” property of the chromatin is specific in that chromatin or nuclei of responsive cells accept more receptor than do preparations from non-responsive cells1,4,5. We know that the non-histone chromatin proteins provide this specificity but the way in which this is achieved is in doubt. Spelsberg et al.4–6 indicate that a non-histone protein is the acceptor in the progesterone/chick oviduct system (“active” role of non-histone proteins) whereas King et al.1,7 proposed, on the basis of their receptor-DNA binding studies in the oestradiol/rat uterus system, that DNA is the acceptor and that the non-histone proteins determine the specificity by controlling which regions of the DNA are accessible to the receptor (“passive” role of the non-histone proteins). Here we present further evidence that DNA is an integral part of the acceptor mechanism and discuss these results in relation to the progesterone data.
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