Abstract
The breast cancers were placed in first rank among other cancer types in women, and second rank after lung cancer in terms of death in the World. It is estimated that this cancer has 20/100.000 frequency in east region and 40-50/100.000 frequency west region according to present data in Turkey. Matrix Metalloproteinase (MMP), proteolytic enzymes involve in the breakdown of proteins located in the cell membrane and intercellular matrix such as collagen, elastin, proteoglycans, and gelatin. The tissue inhibitors of metalloproteinases (TIMPs) are proteins which are specific and natural inhibitor for MMPs. Its primary tasks regulate the activation of MMPs by suppress. The destruction of the balance between MMPs and TIMPs, may lead the emergence of pathological processes. In this study, the effect of TIMP2 (-418) G/C andTIMP2 (303) G/A polymorphisms in breast cancer patients in Turkish population were analyzed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).The statistically significant difference was found between the control group and patients with breast cancer. However it is found that TIMP2 (303) GA genotype increases the risk of developing breast cancer at 1.486fold (p=0519), TIMP2 (-418) CC genotype increases the risk of developing breast cancer at 3.719-fold (p=0.519). In our knowledge, this study is the first to evaluate the relationship between breast cancer and TIMP2 gene polymorphisms in Turkish population. Our results show that there is no any association between breast cancer and TIMP2 gene polymorphisms in the community which is represented by our study and control groups. It was concluded from results that TIMP2 (303) GA genotype ile TIMP2 (-418) CC genotype may create the susceptibility to breast cancer.
Highlights
The breast cancers were placed in first rank among other cancer types in women, and second rank after lung cancer in terms of death in the World
Our results show that there is no any association between breast cancer and TIMP2 gene polymorphisms in the community which is represented by our study and control groups
Matrix metalloproteinases and their inhibitors: correlation with invasion and metastasis in oral cancer
Summary
Meme Kanserinde TIMP2 Gen Polimorfizmleri enzimlerinin özgül ve doğal inhibitörleri olan proteinlerdir. Bu çalışmada TIMP2 (-418) G/C ile TIMP2 (303) G/A polimorfizmleri ile Türk toplumundaki meme kanseri arasındaki ilişkisi Polimeraz Zincir Reaksiyonu-Restriksiyon Fragment Uzunluk Polimorfizmi (PZR-RFLP) yöntemiyle incelendi.Yapılan istatistiksel analizler sonucunda meme kanseri hastaları ile kontrol grubu arasında istatistiksel olarak anlamlı bir fark bulunamamıştır. Hücre dışı matriksin en az bir komponentini proteoliz edebilen Matriks Metalloproteinazlar (MMP)’ler, 21’den fazla üyesi olan çinko bağımlı endopeptidaz enzim ailesidir. Öncelikli görevleri MMP’leri baskılamak ve aktivasyonlarını düzenlemek olan TIMP’ler hücre dışı matriksin depolanması ve yıkımı arasındaki dengenin sürdürülebilmesinde anahtar rol oynarlar. Bu amaca uygun olarak bu çalışmada TIMP2 (-418) G/C ile TIMP2 (303) G/A polimorfizmlerinin Türk toplumundaki meme kanseri hastalarında etkin rol oynayıp oynamadığı Polimeraz Zincir Reaksiyonu-Restriksiyon Fragment Uzunluk Polimorfizmi (PZR-RFLP) yöntemiyle incelendi
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call