Abstract
Voriconazole is an antifungal agent that is commonly used to treat fungal infections. Like any drug, it can cause side effects, especially in the case of overdose. Few cases of hyperkalemia have been reported, which presented when the serum voriconazole level was elevated or when there was voriconazole-drug interaction. We present here a case of voriconazole-induced hyperkalemia, prescribed for an oral candidiasis due to Candida glabrata in a patient hospitalized for severe COVID-19 pulmonary infection. Inflammation due to COVID-19 may play a role in the variability of voriconazole concentrations and then in hyperkalemia.
Highlights
Voriconazole is a second-generation triazole antifungal agent [1]
Voriconazole-induced hyperkalemia has been reported in few cases
We present here a case of acute severe hyperkalemia caused by voriconazole in a patient having a severe inflammation due to COVID-19
Summary
Voriconazole is a second-generation triazole antifungal agent [1]. It is generally well tolerated [2]. Voriconazole-induced hyperkalemia has been reported in few cases. We present here a case of acute severe hyperkalemia caused by voriconazole in a patient having a severe inflammation due to COVID-19. A causal relationship between voriconazole and hyperkalemia was concluded because hyperkalemia was resolved by discontinuing this drug. We review by searching in Pub Med from inception to February 2021, all cases of voriconazole-associated hyperkalemia
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