Abstract
ABSTRACT Objective: This study evaluated the effectiveness of nano bioactive glass 45S5 in promoting enamel remineralization and inhibiting demineralization, comparing it to traditional fluoride varnish and CPP-ACP treatments. Materials and Methods: Forty-five freshly extracted human permanent premolar teeth were sectioned and exposed to a demineralization solution for 48 hours. The teeth were then treated with fluoride varnish (Group I), CPP-ACP paste (Group II), or nano bioactive glass 45S5 paste (Group III) for 10 days. Vickers microhardness was measured at three time points: baseline, postdemineralization, and postremineralization. Data were analyzed using one-way ANOVA, followed by post hoc tests for pairwise comparisons. Results: Significant differences in enamel hardness were observed across all treatment groups at baseline (P < 0.001). After demineralization, Group III (bioactive glass) exhibited the highest postdemineralization hardness (P = 0.050). Post remineralization, Group III demonstrated the highest hardness (P < 0.05). Conclusion: Bioactive Glass 45S5 showed superior remineralization and demineralization inhibition compared to traditional fluoride varnish and CPP-ACP treatments.
Published Version
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