This chapter offers an introduction to the Industrial Applications volume. We review recent trends in approvals of chiral new chemical entities (NCE) and the potential link and implications to the development of asymmetric methods and strategies for medicinal and process chemists. Recent trends across the industry since the publication of the first edition of the volume are discussed and exemplified via two recent case studies using COVID-19 antivirals, molnupiravir and nirmatrelvir.

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