Intravitreal ranibizumab injection combined trabeculectomy versus Ahmed glaucoma valve implantation in the treatment of neovascular glaucoma

Abstract

Objective To evaluate and compare the efficacy and safety of intravitreal ranibizumab injection combined trabeculectomy and intravitreal ranibizumab injection combined Ahmed glaucoma valve implantation in the treatment of neovascular glaucoma (NVG). Methods A retrospective case-control study was designed.The clinical data of seventy-six eyes of seventy-six patients with NVG who received intravitreal ranibizumab injection combined trabeculectomy or Ahmed glaucoma valve implantation were collected in Jingmen NO.2 People's Hospital between May 2013 to May 2015.The eyes were divided into two groups according to different surgical methods: intravitreal ranibizumab injection combined trabeculectomy group (40 patients 40 eyes) and intravitreal ranibizumab injection combined Ahmed glaucoma valve implantation group (36 patients 36 eyes). The surgical success rate, intraocular pressure (IOP), number of antiglaucoma medications used, best correct visual acuity and postoperative complications were analyzed between the two groups. Results Compared with preoperative IOP, the postoperative IOPs in the two groups were all significantly decreased, with significant differences between them (P 0.05). Conclusions Intravitreal ranibizumab injection combined trabeculectomy and intravitreal ranibizumab injection combined Ahmed glaucoma valve implantation are both the effective method in managing NVG.The two different methods have a similar efficacy. Key words: Neovascular glaucoma; Ahmed glaucoma valve; Trabeculectomy