Abstract
Many different radionuclides are in use or being considered for use in radiation therapy with radionuclides. Examples include the traditional uses of radioiodine for treatment of thyroid disorders (hyperthyroidism, thyroid cancer), the use of monoclonal antibodies, peptides, and other agents against specific types of cancer, and the use of various bone seeking agents used in the palliation of pain for bony metastases. Estimation of radiation doses for any of these applications involves several complex phases of analysis. Many standard models and techniques are in use, but it is also a time of rapid development of new techniques and approaches. It is indisputable that even the best current methods for calculating radiation dose give only estimates of the radiation dose to patients’ organs, marrow, tumors, blood vessel walls, etc. Use of animal data to predict human dosimetry introduces additional uncertainties into the analyses, as no truly reliable method exists for making this extrapolation. Human dose estimates based on animal data are considered to be reasonable approximations to be used for proceeding with dose estimates based on human data, which are ultimately used to evaluate in the safety and efficacy evaluations of radiopharmaceuticals. Nonetheless, the calculation of radiation dose based on animal data continues to be an important element of the radiopharmaceutical approval process.KeywordsAnimal DataDose EstimateAbsorb Dose RateInternal DoseEffective Dose EquivalentThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Published Version
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