Abstract
One of the most readily appreciated characteristics of the chemokine family is its striking diversity. Despite narrowly confined structural constraints, over 40 distinct human chemokines have been identified (Rossi and Zlotnik 2000). In general, chemokine number and diversity increase as organisms climb the evolutionary ladder, suggesting that this protein family evolved pari passu with specialized leukocyte subtypes in order to control their specific trafficking patterns. This view of the chemokine world leads to an implicit assumption that chemokines may have definite functions that are restricted in some manner to their target cells.
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