Abstract
Association between interleukin-1 beta (IL-1β) rs1143627 polymorphism and periodontal disease susceptibility was inconsistent; hence we performed this meta-analysis to explore the precise correlation between them. The degree of association was appraised through calculating pooled odds ratio (OR) and its 95% confidence interval (CI). The databases known as PubMed, Embase, and Chinese National Knowledge Infrastructure were searched up to October 26, 2016. A total of 8 eligible case-control studies were finally included, which involved 229 aggressive periodontitis patients, 382 chronic periodontitis patients, and 555 healthy controls. All the five genetic models revealed a non-significant association between IL-1β rs1143627 polymorphism and periodontal disease susceptibility (TT vs. CC: OR = 1.22, 95% CI = 0.80-1.87; CT+TT vs. CC: OR = 0.66, 95% CI = 0.44-1.01; TT vs. CT + CC: OR = 1.19, 95% CI = 0.81-1.74; T vs. C: OR = 0.92, 95% CI = 0.81-1.12; CT vs. CC: OR = 0.92, 95% CI = 0.69-1.23). Sensitivity analyses indicated that the results were robust and the subgroup analyses reached similar conclusions. IL-1β rs1143627 polymorphism is not related to periodontal disease susceptibility in the overall population based on the current evidence, but further studies are required in more large scale sample size with risk factor adjusted.
Highlights
Periodontal disease, a multifactorial disease, is mainly composed of chronic periodontitis (CP) and aggressive periodontitis (AgP) [1,2,3]
IL-1β rs1143627 polymorphism is not related to periodontal disease susceptibility in the overall population based on the current evidence, but further studies are required in more large scale sample size with risk factor adjusted
Meta-analyses have proven that IL-1β rs1143634 polymorphism is significantly connected with the increased risk of CP [12,13], especially for white adults [14]; whereas, no significant association was discovered between IL-1β rs16944 polymorphism and CP susceptibility [15]
Summary
Periodontal disease, a multifactorial disease, is mainly composed of chronic periodontitis (CP) and aggressive periodontitis (AgP) [1,2,3]. It is of great significant to detect periodontal disease activity and to predict treatment efficacy genetically. A variety of publications have reported the potential association between interleukin (IL) polymorphisms and periodontal disease. Meta-analyses have proven that IL-1β rs1143634 polymorphism is significantly connected with the increased risk of CP [12,13], especially for white adults [14]; whereas, no significant association was discovered between IL-1β rs16944 polymorphism and CP susceptibility [15]. IL-1β rs1143634 polymorphism is correlated with CP [12,13,14] but has nothing to do with AgP [1]
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