Cyclooxygenase-2, Fc?? Receptor IIIb, Vitamin D Receptor, Tumor Necrosis Factor-?? 及 Lymphotoxin-?扆穧]多型性與台灣人罹患牙周炎易感性之相關性

Abstract

Objectives: The host-activated immunological and inflammatory reactions responding to bacterial challenge that result in destruction of periodontal tissue are under genetic control. Polymorphisms of genes may affect the function or expression of genes which in turn might affect the expression of periodontal disease. Genetic variants associated with proinflammatory cytokine production and receptor expression might alter the individual susceptibility to periodontitis. The purpose of the present study was to evaluate the association of cyclooxygenase-2-765(COX-2), FcγRIIIb, vitamin D receptor (VDR), tumor necrosis factor -α-308 (TNF-α) and lymphotoxin-α+252 (LT-α) genetic polymorphisms with susceptibility to periodontitis in Taiwanese. Material and methods: There were three groups of study subjects: aggressive periodontitis patients, chronic periodontitis patients and periodontally healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The distribution of genotypes among groups was compared by chi-square test. The risk for periodontitis associated with genotypes was calculated by logistic regression and was expressed as the odds ratio and 95% confidence interval. Results: The genotypes distribution of COX-2-765, FcγRIIIb, BsmI-, FokI-VDR polymorphisms were significantly different among groups. The COX-2-765 genotypes carrying the C allele and the VDR BsmI-RFLP genotypes carring the B allele were associated with the reduced risk of aggressive periodontitis and chronic periodontitis. The NA2 carrier of FcγRIIIb and the VDR FokI-RFLP FF genotypes were significantly associated with the increased risk of aggressive periodontitis. On the other hand, the NA1 carrier of FcγRIIIb might increase the susceptibility for chronic periodontitis. The other genotypes determined in the present study were not associated with the risk of periodontitis. Conclusions: The COX-2-765 C allele and the VDR BsmI-RFLP B allele might be the genetic protective factors for our study subjects against the development of periodontitis. The NA2 carrier of FcγRIIIb and the VDR FokI-RFLP FF genotypes might be the genetic risk factor for aggressive periodontitis. Susceptibility for chronic periodontitis was related to FcγRIIIb NA1 carrier.