Abstract
BackgroundMatrix metalloproteinase-1 (MMP-1) plays an important role during the destruction of periodontal tissue. Although multiple studies had focused on the association between MMP-1 g.-1607dupG and periodontitis susceptibility, the results remained inconclusive. The purpose of this meta-analysis was to explore its role in the development of periodontitis.MethodsRetrieved studies from Pubmed, Web of Science, Medline and Google Scholar Search regarding MMP-1 g.-1607dupG and periodontitis susceptibility were included into the final analysis with definite selection and exclusion criteria. Overall and stratified analyses based on disease type, severity, ethnicity and smoking status were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between MMP-1 g.-1607dupG and periodontitis susceptibility, while Q test and Egger’s test were adopted respectively to assess heterogeneity among studies and publication bias.ResultsA total of 1580 periodontitis cases and 1386 controls in 11 case-control studies were included in the meta-analysis. The pooled results showed significant association between periodontitis susceptibility and MMP-1 g.-1607dupG polymorphism in homozygote (2G/2G versus 1G/1G, OR = 1.50, 95% CI = 1.02–2.20) and dominant model analysis (2G/2G+2G/1G versus 1G/1G, OR = 1.28, 95% CI = 1.04–1.57). For subgroups by type of periodontitis, increased risk of chronic periodontitis was observed on heterozygote (2G/1G versus 1G/1G, OR = 2.01, 95% CI = 1.58–2.56) and dominant model (OR = 1.27, 95% CI = 1.03–1.57). Furthermore, similar association was also detected in severe chronic periodontitis (2G/2G versus 1G/1G, OR = 2.15, 95% CI = 1.35–3.43; 2G/2G+2G/1G versus 1G/1G, OR = 1.64, 95% CI = 1.12–2.39; 2G/2G versus 2G/1G+1G/1G, OR = 1.86, 95% CI = 1.31–2.64).ConclusionsOur meta-analysis demonstrated that MMP-1 g.-1607dupG polymorphism was associated with chronic periodontitis, especially the severity of the disease condition.
Highlights
Periodontitis are of the most common oral diseases around the world with high prevalence of 10%–15% [1], constituted by two major types: chronic periodontitis (CP) and aggressive periodontitis (AgP)
It is worth noting that fibrillar collagens types I and III, the predominant types of interstitial collagens in periodontium which are resistant to most proteinases, can be degraded by Matrix metalloproteinase-1 (MMP-1) [19]
Search Strategy and Data Extraction To systematically retrieve all the case-control studies related to the association between Matrix metalloproteinases (MMPs)-1 g.-1607dupG and periodontitis risks, databases of PubMed, Web of Science, Medline and Google Scholar Search were searched with the key words ‘‘periodontitis’’, ‘‘MMP-1’’ and ‘‘polymorphism’’
Summary
Periodontitis are of the most common oral diseases around the world with high prevalence of 10%–15% [1], constituted by two major types: chronic periodontitis (CP) and aggressive periodontitis (AgP). As kinds of inflammatory diseases, they could cause great periodontium damage by interaction between pathogens challenge and host immunological reaction [2,3], and contribute to tooth loosening and loss. Their potential adverse effects on systemic health [4], such as adverse pregnancy outcome [5], diabetes mellitus [6], cardiovascular disease [7,8] and some other general diseases [9,10], should be paid much attention to. Multiple studies had focused on the association between MMP-1 g.-1607dupG and periodontitis susceptibility, the results remained inconclusive The purpose of this meta-analysis was to explore its role in the development of periodontitis
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