Abstract
THE effects of interferon on gene expression are still in debate. To explain the block in the multiplication of both DNA and RNA viruses, it was proposed that interferon affects the translation of viral mRNA, but not that of cellular or synthetic mRNAs1–5. Because active cell-free systems which translate purified mRNA were not available at the time, evidence for these effects remained suggestive but inconclusive. Very recently, marked inhibitions of virion associated transcriptases in interferon-treated cells have been reported6,7; but again, the proposed effects of interferon treatment on transcription6–8 have not been demonstrated in cell-free systems. As a cell-free system from interferon-sensitive mouse L cells, active for the in vitro translation of natural mRNAs, is now available9–11 we have reinvestigated the influence of interferon treatment on the translation of viral and cellular mRNAs.
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