Abstract
Interactions between neurotropic pathogens, neuroinflammatory pathways, and autophagic neural cell death
Highlights
Neurotropism of certain microbial pathogens could lead to neurological health problems in humans
It is suggested that chronic infections in the central nervous system (CNS) might be associated with progressive www.nnjournal.net
The main purpose of the present review is to find out possible interactions of neurotropic intracellular pathogens with neuronal cell autophagic process favoring the pathogen(s) for their intracerebral survival, as well as multiplication in CNS infectious diseases
Summary
Neurotropism of certain microbial pathogens could lead to neurological health problems in humans. The interactions between different CNS intracellular pathogens and autophagic genes, along with the resulting autophagic and inflammatory processes are being studied. The presence of pathogenic antigens can induce autophagic genes through a stratified array of principal immunological processes, and result in augmented autophagy and inflammation at the site of infection, which limits bacterial proliferation.
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