Interaction of platinum(II) amino acid complexes with nucleosides

Abstract

We report the synthesis of mixed ligand complexes of platinum(II) with glycine or alanine as primary ligands and the nucleosides adenosine, guanosine, inosine, cytidine and uridine as secondary ligands. Interaction of platinum(II) amino acid complexes with nucleosides was carried out in a 1:1 ratio, resulting in the formation of cis dichloro complexes. It was found that adenosine and guanosine coordinate to the metal ion through N (7), whereas inosine binds through N (1). The pyrimidine nucleosides coordinate to the metal ion through N 3. In these complexes the amino acid behaves as a monodentate ligand coordinating through the amino nitrogen. These complexes are insoluble in aqueous medium but on addition of base they become soluble due to the neutralization of the proton located on the carboxylic group of the amino acid.