Abstract
This article aimed to synthesis, spectroscopic, physicochemical characterizations, and catalytic studies on some ofloxacin (OFL) complexes with ruthenium(III) [Ru(III)] metal ions. The Ru(III)-OFL complex, [Ru(OFL)2(Cl)2]Cl and two mixed-ligand complexes, [Ru(OFL)(AA)(H2O)2]Cl2 derived from OFL as the primary ligand and amino acids [AA; either glycine (Gly) or alanine (Ala)] as the secondary ligands, were synthesized and characterized using microanalytical, spectroscopic, and physical techniques including element composition, molar conductivity, infrared, electronic spectra, thermal, X-ray powder diffraction (XRD), Energy dispersive X-ray spectroscopy (EDX), Scanning electron microscopy (SEM), and Transmittance electron microscopy (TEM) analyses. The element analysis data describe the formation of 1:2 [Ru(III):OFL] and 1:1:1 [Ru(III):OFL:AA] complexes. The octahedral geometry of the complexes was confirmed by their magnetic moment and diffused reflectance. Fourier Transform Infrared spectroscopic (FTIR) measurements suggested that the ligands chelated with Ru(III) ions through the nitrogen atoms of the piperazine ring. In vitro antibacterial efficiency of the OFL compounds was evaluated by paper disc diffusion method. Significant antimicrobial activities were observed for some compounds of the series.
Highlights
Fluoroquinolones are broad-spectrum antibiotics effective against gram-negative organisms, notably Pseudomonas aeruginosa
All solvents were obtained from the Fluka Chemical Company (London, UK), Glycine from
The negative values for both were attributed to the stability of the values for both EHOMO and ELUMO were attributed to the stability of the synthesized complexes
Summary
Fluoroquinolones are broad-spectrum antibiotics effective against gram-negative organisms, notably Pseudomonas aeruginosa They are often used to treat infections like pneumonia [1,2,3]. Chelation modes have been reported quinolones metal thethe activity of the the compound [19,20,21,22,23]. Four chelation modes havefor been reportedregarding for quinolones quinolones regarding metal ions, as described in [24,25,26,27,28]. These were complexes were structurally using FTIR, XRD, SEM, and EDX, and analyzed to determine their antibacterial efficiency against two of Gram (+) and Gram (−) species
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