MIXED LIGAND COMPLEXES OF PLATINUM(II) WITH α-AMINO ACIDS AND PURINES AND PYRIMIDINES

Abstract

Abstract The synthesis and characterization of mixed ligand complexes of platinum(II) with amino acids as primary ligands and purine and pyrimidine bases as secondary ligands are reported. The interaction of platinum(II) glycine and alanine complexes with purine and pyrimidine, carried out in a 1 : 1 ratio resulted in the formation of mixed ligand complexes. In these complexes adenine and guanine are coordinated to the metal ion through N(7) whereas hypoxanthine acts as a bridging ligand coordinating through N(3) and N(9). The pyrimidines are coordinated to the metal ion through N(3). In all the mixed ligand complexes the amino acids behave as monodentate ligands coordinating through amino nitrogen.