Abstract
ABSTRACT Detergent solubilized, partially purified mouse H-2 antigens have been reconstituted in phosphatidylcholine and phosphatidylcholine/cholesterol lipid vesicles. These lipid vesicles inhibit lysis by alloantibody and complement and inhibit specific conjugate formation between alloimmune cytotoxic T lymphocytes and target cells. With this system the influence of antigen density and lipid composition on immune recognition can be studied.
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