Abstract
The cover picture shows ethyl bromodifluoroacetate directly reacts with azaindole without transition metal catalysis to produce a difluoromethyl protected 5‐aldehyde group product in one step. It is worth mentioning that the reacted aldehyde group is only formed at the 5 position. In addition, this method has good substrate applicability and functional group tolerance. Finally, the author also carried out some mechanism auxiliary experiments, which confirmed that the aldehyde‐based carbon comes from ethyl bromodifluoroacetate. More details are discussed in the article by Li et al. on page 1477–1482.image
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have