Abstract
AbstractAn efficient method for the copper‐catalyzed selective C−H difluoroalkylation of coumarins and with low cost and readily available ethyl bromodifluoroacetate and N‐phenyl bromodifluoroacetamide has been reported. This reaction exhibits good functional group tolerance with respect to coumarins and difluoroalkylation reagents, and several redox‐sensitive substrates have been successfully C−H difluoroalkylated in good to high yield. This design could further expand the scope to other heteroarenes, including furan, benzofuran, pyrrole, pyridinone, chromenone, indole, and quinolinone. A mechanism involving copper‐catalyzed in‐situ generation of fluoroalkyl radical is proposed.
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