Abstract
Cardiovascular diseases (CVDs) have been the leading cause of death worldwide for many years. In recent years, new CVD markers have been sought that can improve the diagnosis and treatment of this broad and predictably unfavorable group of diseases. The efforts of many researchers are aimed at identifying changes in the level of enzymes in the lipid peroxidation system as possible mechanisms underlying the development of CVDs. The imbalance between the intensification of free-radical oxidation caused by active oxygen forms and the activity of the body’s protective antioxidant system leads to serious disturbances: disorganization of cellular structures, changes in their functional activity. The article presents the study of the interrelations between the concentration distribution of POL-AO enzymes in blood serum and heart tissues of white non-pedigree rats. The correlation coefficients of Spearman, the gamma of correlation and Kendel Tau revealed a reliable presence of weak correlation between the concentration of glutathione peroxidase in blood serum and heart tissues (Spearman R = 0.18 at p < 0.029408, Gamma = 0.14 at p < 0.018701; Kendall Tau = 0.13 at p < 0.018701).
Highlights
The highest prevalence of cardiovascular disease (CVD) is responsible for increasing mortality and disability among the working population in economically developed countries
The search for the root causes of etymology of various diseases leads to the concept of oxidative stress, which develops against the background of homeostatic imbalance of the body under the influence of endo- and exogenous factors
The main suppliers of ROS in heart tissues are NADPHoxidase concentrated in blood phagocytes, tissue macrophages, mitochondria of oxygendependent cardiomyocyotes, the latter being the main consumers of molecular oxygen for redox ATP synthesis reactions
Summary
The highest prevalence of cardiovascular disease (CVD) is responsible for increasing mortality and disability among the working population in economically developed countries. The main suppliers of ROS in heart tissues are NADPHoxidase concentrated in blood phagocytes, tissue macrophages, mitochondria of oxygendependent cardiomyocyotes, the latter being the main consumers of molecular oxygen for redox ATP synthesis reactions. Intensification of redox processes enhances the formation of ROS such as peroxynitrite, superoxide anion and others, provokes vascular endothelial dysfunction, depriving it of the ability to adapt to changes in hemodynamics, increasing vasoconstriction, which in turn leads to the development of a number of diseases: hypertension, renovascular and malignant arterial hypertension, dyslipidemia, thrombosis, metabolic syndrome, diabetic and dilatational cardiomyopathy, atherosclerosis, ischemic heart disease, arterial hypertension (AG), diabetes mellitus [6, 7, 8, 9, 10]. Digital material was statistically processed by nonparametric Spearman correlation analysis, as well as by using gamma correlation coefficients and Kendella Tau
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