Abstract
It is known that the majority of pathological processes take place against the background of formation of active oxygen species and intensification of free radical oxidation of bio-substrates. In response to this, the antioxidant system of the cell is activated, and the glutathione system is an important link in this system. The latter can take part in the maintenance of the optimal state of biomembranes, in the processes of detoxification, antioxidant protection, etc. The biological role of glutathione reductase is to maintain high intracellular concentration of reduced glutathione. The aim of our study was to study the relationship between the distribution of glutathione reductase activity in blood serum and rat tissues. In order to achieve the goal of the study the following tasks were solved: the activity of glutathione reductase in blood serum and tissues of liver, brain, heart, as well as in skeletal muscle tissues of rats was determined; the interrelation of the activity distribution of glutathione reductase in blood serum and tissues of rats was revealed. The article presents the results of nonparametric correlation analysis to assess the relationship between the distribution of glutathione reductase activity in blood serum and tissues of small experimental animals.
Highlights
Habitats constantly and continuously affect living organisms through abiotic and biotic factors
The ability to maintain high levels of functioning of physiological systems in conditions of maximum intensity of loading is designated as functional stability and it allows maintaining maximum efficiency
At the first stage of the statistical analysis we tested for compliance with the normal distribution of GR activity in blood serum and rat tissues
Summary
Habitats constantly and continuously affect living organisms through abiotic and biotic factors. The process of survival of living organisms in constantly changing conditions is called adaptation. As a result of the action of any irritant in accordance with the studies of F.Z. Meerson (1981, 1988) there is a process of urgent adaptation, in which the body functions with the maximum mobilization of internal reserves. Meerson (1981, 1988) there is a process of urgent adaptation, in which the body functions with the maximum mobilization of internal reserves In this mode, the reserves are quickly exhausted; the body's reaction becomes short-term and turns into a stressresponse. Sustainable (long-term) adaptation is formed gradually as a result of long and repeated exposure to the environment, when quantitative changes are transformed into qualitative, economical reactions that allow a body functioning within the limits of physiological norms. By activating the «stress-limiting systems of the body» it is possible to provide adaptation to changing environmental conditions [2]
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