Abstract

ABSTRACT Graphite-modified magnetite (Fe3O4) has been incorporated to brushite bone cement to prepare novel injectable magnetic bone cement (NIMC) for hyperthermia. The results reveal that NIMC with a setting time of 30 min is injectable and anti-washout. Under the magnetic field of 1.59 × 106 A/m, the saturation magnetisation of NIMC is 28.01 A·m2/Kg, higher than that of the contrast with non-modified magnetite. Moreover, after exposed to an alternating magnetic field (340 kHz, 1.13 × 103 A/m) for 200 s, the specific absorption rate values of NIMC and the contrast are 30.20 W/g and 18.75 W/g, respectively. NIMC displays much better heating ability than the contrast. Moreover, IMBC has no cytotoxicity to MG-63 cells, and MG-63 cells can adhere and spread on the cement after co-culturing for 7 days. Therefore, this novel magnetic bone cement has the potential to be used for hyperthermia.

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