Inhibitory effects of gold nanoparticles biosynthesized by redox reaction using Rheum ribes lam fruit peels on pathogen strains and cancer cells

Abstract

ABSRACT Gold nanoparticles (AuNPs) are very valuable materials used in many fields, especially in biomedical applications. In this study Rheum ribes Lam-derived AuNPs (Rrib*AuNPs) were synthesized in an environmentally friendly, easy and low-cost method using the extract obtained from the waste skin of the fruit known as Rheum ribes Lam (Kurdish banana). Functional groups of phytochemicals responsible for redox reactions were determined by FTIR data. Properties of synthesized Rrib*AuNPs UV-vis, TEM, FE-SEM, Zeta potential, XRD, AFM, TGA-DTA), EDX), Zetasizer devices. In the characterization data, it was determined that Rrib*AuNPs had an average size distribution of 58.27 nm, a spherical appearance morphology, a maximum absorbance of 543.96 nm, a surface charge of −23.0 mV, a monodisperse and stable structure. It was determined by microdilution that the synthesized Rrib*AuNPs had antibacterial and anti-fungal effects with 0.03–0.50 µg ml−1 Minimum Inhibition Concentration amounts. The cytotoxic effects of Rrib*AuNPs on cancer and healthy cell lines were investigated using the MTT method.