Abstract
AN inhibitor of the RNA-dependent DNA polymerases1,2 of mammalian C-type viruses was found in sera from rats bearing transplantable tumours, induced by murine C-type RNA tumour viruses3,4. Partially purified polymerases of murine leukaemia virus3 and feline leukaemia virus (FeLV)4 were shown to be antigenic in rabbits and a rat, respectively. We have detected an inhibitor of the DNA-dependent DNA polymerase5,6 of feline and murine C-type viruses in the sera of cats inoculated in utero and/or postnatally with the Gardner-Arnstein strain of feline sarcoma virus (FSV)7 and in the sera of cats bearing spontaneous sarcomas, lymphomas or carcinomas.
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