Abstract
Cellulosic materials are important resources for the production of fuels and chemicals. One of the processes designed to utilize cellulosic materials is enzymatic hydrolysis followed by fermentation to final products. It was shown that simultaneous saccharification and fermentation (SSF) is effective in the production of ethanol from cellulose. The acceleration of the rate of cellulose degradation in SSF was caused by less inhibition of cellulase by ethanol than by glucose and/or cellobiose. In order to apply the SSF method effectively to the production of substances derived from glucose by fermentation, several conditions should be satisfied. One of them is the coincidence of conditions of enzymatic hydrolysis and fermentation of hydrolyzate, such as pH and temperature. The second condition is that the inhibition of cellulase by the final product is less than that by glucose and/or cellobiose. There has been a comprehensive review and some reports on inhibition of cellulase by saccharides such as glucose, cellobiose, xylose, lactose, maltose, metals, and some chemicals such as dyes, detergents, halogenated compounds, and phenolic compounds. In this communication, the inhibition of cellulase by several substances derived by fermentation of glucose is reported. 7 references.
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