Abstract
Publisher Summary This chapter highlights inhibition of cell division. It is assumed that all of the biochemical and physiological events involved in the process of cell division can be dissociated from one another by selective experimental inhibition. By focusing on the behavior of the chromosomes, three major physiological events that occur during cell division can be established: chromosome reproduction, chromosome movement, and cytoplasmic cleavage. If chromosome reproduction is inhibited, chromosome movement and cytoplasmic cleavage will not take place. If chromosome movement is inhibited, the third event will not occur; and if cytoplasmic cleavage is blocked, the end result of cell division, the formation of two daughter cells will not be achieved. Thus, all three events normally occur with strict continuity, are interdependent, and can be dissociated from one another by appropriate inhibitors. An independent, continuous, and dissociable biochemical event involves the cyclic increase in respiration that occurs during interphase. This can be demonstrated in sea urchin eggs, where the normal rhythmic increase in oxygen consumption persists even though cell division is blocked at metaphase.
Published Version
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