Abstract
Not only can chemicals enhance the cellular damage of near-UV light (photosensitization), but we now report that previous exposure to near-UV light can enhance chemically induced cellular damage. Fertilized sea urchin eggs were used to test all trans retinol, retinal, and retinoic acid as near-UV photosensitizers. Inhibition of cell division was not observed when fertilized eggs were exposed to the light in the presence of retinol or retinal. Retinoic acid and UV-exposure together partially prevented cell division. When fertilized or unfertilized eggs were pre-exposed to near-UV light and then 10-4M retinoic acid added to the cultures, cell division was totally prevented. The inhibition of cell division was not observed due to any combination of UV exposure and/or addition of retinol or retinal. This work shows that near-UV light can sensitize the direct retinoic acid-mediated prevention of sea urchin egg division.
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