Informative value of the clinical parameters of metabolic syndrome at primary acute ischemic stroke

Abstract

The aim of research is determination of connection between the ischemic insult and the number of components of metabolic syndrome (MS).Methods. The research included 160 patients with initial acute ischemic stroke: 103 patients with MS diagnosis and 58 without MS. All patients were equal by age and sex.All patients underwent clinic-neurological, laboratory and instrumental examinations.The subtype of stroke was detected according to TOAST classification. At statistic processing there were used xi-square and Mann-Whitney test.Results. At detection of MS it was revealed: with 3 components – in 31,4% of patients, with 4ones – in 40,2% of patients, with 5 ones - in 28,4% of patients. Among the atherothrombotic subtype prevailed patients with 4 components of MS, among cardioembolic one – with 3, with lacunar one there were not revealed any changes.The indices of high arterial pressure and of hyperthiglyceridemia of the heavy degree prevailed in patients with 4 and 5 MS components. The increase of MS components number caused the more intensive hyperglycemia in patients. According to indices of glycosylated hemoglobin there was established that the prevalence of chronic disorder of carbohydrate metabolism was detected only at lacunar subtype of stroke and only in patients with 5 MS components.Conclusions. There was established that the increase of MS components number worsens the hemodynamic indices, deepens atherothrombotic potential that correlates with data of the blood lipid spectrum and the degree of heaviness of carbohydrate-metabolic changes