1979 RELATIONSHIP BETWEEN NEPHROLITHIASIS AND COMPONENTS OF METABOLIC SYNDROME IN KOREAN ADULTS

Abstract

You have accessJournal of UrologyStone Disease: Basic Research1 Apr 20101979 RELATIONSHIP BETWEEN NEPHROLITHIASIS AND COMPONENTS OF METABOLIC SYNDROME IN KOREAN ADULTS Young Sam Cho, Kwan Joong Joo, Heung Jae Park, and Chil Hun Kwon Young Sam ChoYoung Sam Cho More articles by this author , Kwan Joong JooKwan Joong Joo More articles by this author , Heung Jae ParkHeung Jae Park More articles by this author , and Chil Hun KwonChil Hun Kwon More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1989AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Metabolic syndrome(MS) and nephrolithiasis(NL) are common disorders. Some of the components of metabolic syndrome have been proposed as precursors of NL. It is not known, however, whether MS is associated with components affecting NL. The objective of the study was to evaluate the relationship between NL and components of MS in Korean adults. METHODS Between January 2008 and December 2008, a total of 56,066 adults who visited our health promotion center and no previous history of NL were enrolled. The MS diagnosis was performed according to the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III). The presence of NL was assessed by ultrasound examination of kidneys and upper urinary tract. RESULTS The mean age was 44 (±9.1) years and the prevalence of MS in NL group and other group were 14%, 11%, respectively (p<0.05). Among the individual components of MS, abdominal obesity, high blood pressure and HDL-C(high-density lipoprotein cholesterol) were independently related to echographic evidence of NL (Table). The results were further analysed separately in male and female participants. The prevalence of MS in NL group in male and female were 16.5%, 8.2%, respectively. Compared to 13.3% and 7.8% in NL-free group, there was no statistically significant difference. In a multivariate logistic regression model, central obesity and hypertension were independent risk factors of NL (odds ratio 2.1, 1.7, respectively) in female. When divided into three groups (0, 1-2, ≥3) based on the sum of MS components, the odds ratios were 1.2 in 1-2 group and 1.4 in ≥3 group. CONCLUSIONS MS is significantly associated with echographic evidence of NL. Central obesity, hypertension were independent risk factors of NL in female. The odds ratio of NL showed differences according to increasing sums of MS components. The efforts of detection and treatment of MS may be helpful to decreasing development and recurrence of NL in adults. Seoul, Republic of Korea© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e768 Peer Review Report Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Young Sam Cho More articles by this author Kwan Joong Joo More articles by this author Heung Jae Park More articles by this author Chil Hun Kwon More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...