Abstract
Purpose: The complex process of chondrogenesis depends on the coordinated action of numerous signalling pathways. Some of these pathways are sensitive to the changes of intracellular Ca2+ concentration. Calcium influx requires the functional expression of plasma membrane calcium channels, which belong to the ‘chondrocyte channellome’. N-methyl-D-aspartate (NMDA) glutamate receptor is a cation channel with high permeability for Ca2+. There is a growing body of evidence for the expression and function of NMDA receptors in non-neural tissues including mature cartilage and bone.
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