Influence of the preparation “Prodevit-tetra” and “Nanovit” on endogenous intoxication of cows during the dry period

Abstract

It is well known that medium-sized molecules (MSM) affect the tone of smooth muscle structures of organs and the transvascular transport system. MSM also can pass through placental barrier and intoxicate fetus, resulting in multiple organ damage. The goal of the work was to determine the level of endogenous intoxication in cow’s organism on the last trimester of pregnancy and under the influence of the “Prodovit-tetra” and “Nanovit” preparations, as well as calving process and after it. Experiment was conducted in LLC “Agroprodservice invest” of Ternopil oblast on the cows of Ukrainian black-and-white dairy breed. Biochemical studies conducted in the laboratory of veterinary obstetrics and gynecology of the Ternopil Research Station of the Institute of Veterinary Medicine of the NAAS. One control and two experimental groups of animals were used for this experiment. Cows of the first experimental group received 15.0 ml of “Prodevit-tetra” preparation intramuscularly on the 35–25 day before calving. Blood was taken from the observed animals before and after administration of the medicines. The level of endogenous intoxication of the cow’s organism were determined by the concentration of MSM in their blood and prooxidant/antioxidant index. Concentration of MSM in the blood of cows after administration of “Prodevit-tetra” reduced by 41.0% and after administration of “Nanovit” containing metal nanoparticles – by 61.0% that promoted increase of prooxidant/antioxidant index by 1.7 and 2.3 times (Р ≤ 0.001) compered to initial indicators and indicated the positive effect of preparations on the cow’s organism. Application of the “Nanovit” preparation showed better result, therefore we can recommend it to be used in scheme to reduce intoxication of the cows during the dry period and to prevent postnatal pathology. The results of the experiment suggest that multivitamin complex “Nanovit” could be used for reducing of intoxication in the body of cows during dry period and to prevent postnatal pathology. In the future, we will study effect of the “Nanovit” preparation on the humoral immunity of cows in dry period and after calving and possibility of “Nanovit” usage in the system of prevention of obstetric pathology as well.