Influence of Solvent Properties on the Measurement Accuracy of Specific Rotation of Chiral Molecular Solutions Based on Photonic Spin Hall Effect

Abstract

Chirality distinguishing of biomolecules has attracted much attention in numerous fields. When detecting the chirality of molecules based on the optical rotation characteristics, the detection accuracy of specific rotation is closely related to solvent properties. Herein, taking amino acids as an example, in the case of changing the type, potential of hydrogen value, and concentration of solvents, respectively, the specific rotation is measured using spin Hall effect of light based on weak measurement. The results indicate that the specific rotation values of chiral molecules are different in different types of solvents. When phosphate buffered saline is used as the solvent, the detection sensitivity of chiral molecules is higher under alkaline conditions. When the pH value is fixed, the detection performance under the solvent concentration of 0.1 m is better than that of 0.01 or 0.001 m. The study shows that the solvent properties affect the specific rotation detection of chiral molecular solutions. Proper solvent properties can improve its accuracy, which is of great significance to promote the sensitivity of chiral discrimination.