Influence of serum prolactin on the results of echocardiography in patients with stable exertional angina and gastroesophageal reflux disease

Abstract

Objective: to investigate the possible influence of serum prolactin level on the left ventricular myocardial functional capacity in patients with stable exertional angina (SEA) and gastroesophageal reflux disease (GERD). Material and methods. 118 patients were examined. Among them, 30 patients with isolated SEA (I–II FC) who made up 2 groups of study and 88 patients with SEA with comorbid endoscopically positive GERD (A, B, C), who were included in 1 group of the study. The control group consisted of 20 healthy persons (HP). Echocardiography was performed for all patients enrolled in the study and HP to determine the morphofunctional status of the left ventricular myocardium (LV) and its contractile function), to determine the serum prolactin (PL) level. Results. According to the echocardiography of patients with SEA with comorbid GERD, the indices that characterize the contractile capacity of the LV: the final diastolic volume of the LV and the ejection fraction (EF) of the LV are significantly lower than in both healthy subjects and patients with isolated SEA. The PL level of serum of patients with SEA with GERD is significantly higher than that of patients with isolated SEA and in healthy subjects. The incidence of hyperprolactinemia in patients with SEA in the presence of comorbid GERD is 3.1 times higher and is statistically significant (OR = 3.1183; CI 95% 1,326 –7.3331; р< 0,009) compared with the isolated course of CCN. The content of PL in the serum of patients with SEA and GERD is in a strong inverse correlation (r=-0,74, p<0,05) with the left ventricular EF. Conclusion. Therefore, we found that elevated prolactin levels of serum in patients with stable exertional angina and gastroesophageal reflux disease adversely affect the contractile capacity of the left ventricular myocardium, which is confirmed by the established negative high correlation between the serum levels of prolactin and ejection fraction of the left ventricule.