Abstract
It is known that proteins associated with pregnancy provide immune tolerance during pregnancy. One of them is pregnancy-specific β1-glycoprotein (PSG), which has a pronounced immunomodulatory effect. Tetrapeptide fragments (YECE, YQCE, YVCS, and YACS) have been identified in the primary structure of PSG that have immunopharmacological potential. The aim of the study was to evaluate the effect of short peptide fragments of PSG on the morphological and immunohistochemical state of the spleen and its compartments during allogeneic transplantation of a suspension of red bone marrow cells in an in vivo experiment in Wistar rats. It was found that intraperitoneal injection of bone marrow cells in the dynamics of the experiment (35 days) caused splenic hyperplasia with accumulation of lymphoid cells and macrophages in the functional areas of the organ. Administration of short peptide fragments of PSG against the background of allogeneic bone marrow transplantation promotes activation of cells of the immune system in the spleen toward their proliferation (Ki-67) and differentiation, while reducing the content of macrophages (CD68). Thus, short peptide fragments of PSG stabilize proliferative processes and promote the development of adaptive responses in response to an allogeneic graft.
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