Abstract
Earlier investigations revealed different interactions of metal-free and metal-containing thiurams (Fungicides, rubber accelerators) with GST or rat livers. Based on these observations the question arose whether heavy metals alone may influence the activity of GST. In vitro experiments with isolated GFST showed different interactions. The activity of the GSH S-acyltransferases in liver, kidney, lung and brain of mice were enhanced by treatment with CdCl{sub 2}, HgCl{sub 2} or NaCO{sub 3}; in contrast the activity of GSH S-epoxide transferase in the liver of mice was decreased by Cd, Hg or V containing salts. The objective of the authors study was to explore the effects of Pb, Cd, Zn, Mn, Cu, Hg and Be ions on the glutathione-conjugating enzyme system (GSH S-epoxide transferase, GSH S-aryltransferase) during long-term administration (3 months) as compared to in vitro exposure.
Published Version
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