Abstract
Abstract Objective To evaluate the in vivo effect of 14 d repeatedly oral administration of Clinacanthus nutans (C. nutans) methanol leaves extract (250 mg/kg, 500 mg/kg and 1 000 mg/kg bw) on the acetylcholinesterase (AChE) activity in male Balb/C mice. Method First group was served as control group, orally treated with distilled water as vehicle and group 2-4 were orally treated with a single daily dose of 250 mg/kg, 500 mg/kg and 1 000 mg/kg bw of C. nutans extract, respectively for 14 d. Each group consisted of six animals (n =6). The activity of acetylcholinesterase in brain, liver, kidney and heart of mice was determined according to Ellman method (1961). Results From the results obtained, the AChE activity was found to be highest in mice liver, followed by brain, kidney and heart. Methanol extract of C. nutans leaves at 250 mg/kg (P Conclusion In conclusion, 14 d oral administration of C. nutans was able to modulate cholinergic neurotransmission by activating AChE activity in mice kidney, liver and heart. Compounds that responsible for the induction of AChE activity in mice liver, heart and kidney and its mechanism needs to be elucidated.
Published Version
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