Abstract
Newborn mammals exhibit a characteristically biphasic hypoxic ventilatory response (HVR) in which an initial increase in ventilation is followed by a progressive decline toward (or below) baseline values. Studies in anesthetized, newborn piglets suggest that the secondary hypoxic depression is partially attributable to γ‐aminobutyric acid (GABA) signaling through GABAA and GABAB receptors (Huang et al. J Appl Physiol 77:1006–1010, 1994). To determine whether GABAA and GABAB receptors similarly contribute to the biphasic HVR of newborn rats, we measured normoxic (21% O2) and hypoxic (12% O2) ventilation of newborn (P3–5) rats by head‐body plethysmography 30 minutes after intraperitoneal injection with vehicle or a GABA receptor antagonist. Two different GABAB receptor antagonists, CGP‐35348 (200 mg kg−1) and CGP‐46381 (50 or 100 mg kg−1), were found to have no effect on normoxic ventilation or the HVR (all P>0.05). Similar results were obtained for the GABAA receptor antagonist (+)‐bicuculline (2 or 3 mg kg−1). Collectively, these data do not support a role for GABAergic signaling in the biphasic HVR of newborn rats.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Published Version
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