GABA: Receptors, Transporters and Metabolism

Abstract

Opening lecture.- Establishment of GABA as an inhibitory neurotransmitter at Crustacean neuromuscular junction and in the mammalian central nervous system.- Glutamate decarboxylase and autoimmunity.- Physiological aspects of GAD-GABA system in the pancreatic islet.- Membrane associated L-glutamate decarboxylase and insulin-dependent diabetes mellitus (IDDM).- Glutamate decarboxylase, GABA and autoimmunity.- Stiff-Man syndrome and glutamic acid decarboxylase: An updated view.- Anti-GAD antibody in various neurological diseases.- Molecular structure and functional regulation of GAGA transporters.- GABA transporters: Structure, function and mechanism.- Heterogeneity of brain GABA transporters.- Developmental expression of the GABA transporter GAT4.- Functional regulation of GABA transporters by PKC and their distinct localization.- Transmitter release and GABA receptor regulation.- GABAB receptor control of transmitter release in the spinal cord.- Role of GABAA and GABAB receptors in calcium homeostasis and transmitter release in cerebellar granule neurons.- Interactions between endogenous L-DOPA and GABAA systems for cardiovascular control in the rat nucleus Tractus solitarii.- Potentiation by protein kinase C activation of GABA release from Xenopus oocytes injected with rat brain mRNA.- GABA receptor subtypes and functional regulation.- The molecular biology of GABAA receptors and its applications.- Modelling functional domains of the GABAA receptor chloride channel.- GABAA receptor subtypes: Pharmacological significance and mutational analysis in vivo.- Regulation of GABAA receptors by multiple protein kinases.- Enhancement of GABA-induced current by 20-hydroxyecdysone in cultured cortical neurons.- Differential sensitivity during development of GABA-mediated synaptic transmission to a neuroactive steroid in rat hippocampus and cerebellum.- Ontogenic changes of GABAA function of the rat Meynert neuron.- GABAergic system modulates the formation of LTP (long-term potentiation) in the superior colliculus.- GABA receptor-chloride channel complex as a target site of alcohol.- Functional analysis on GABAB receptor using a reconstituted system with purified GABAB receptor, Gi/Go protein and adenylyl cyclase.- Paradoxical facilitation of the voltage-dependent calcium current following activation of GABAB receptors.- Stereospecific GABAB receptor antagonism.- A novel GABA response identified optically in the nucleus of the Tractus solitarius of the chick embryo.- GABAA and GABAB receptor ligands and their therapeutic application.- A novel benzodiazepine partial inverse agonist, S-8510, as a cognitive enhancer.- Spatial benzodiazepine receptor imaging in the human brain.- Does the GABAA receptor have a role to play in Angelman syndrome?.- Modulators of both GABAA receptor and cytosolic calcium level related to a novel treatment for epilepsy.- Muscimol induces state-dependent learning whereas baclofen impairs place learning in Morris water maze task in rats.- GABAB receptor antagonists: Potential therapeutic applications.- Expected therapeutic use of GABA agonists and antagonists for gut motility disorders.- GABAB antagonists block ?-butyrolactone-induced absence seizures and coordinated induction of transcription factors in mouse brain.- Pharmacological studies on generalized absence seizure regulation in genetic and drug-induced models.- Acknowledgements.- Keyword index.