Abstract
Objective To observe the effects of dexmetomidine on the hyperalgesia induced by remifentanil anesthesia in patients with laparoscopic cholecystectomy. Methods Ninety-eight patients who underwent laparoscopic cholecystectomy in the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine from October 2015 to September 2017 were selected and were divided into control group and observation group according to blind selection method, with 49 cases in each group. Patients in control group were given remifentanil to maintain anesthesia, while patients in observation group were given dexmetomidine + remifentanil to maintain anesthesia. Hemodynamic indicators, pain degree and adverse reactions of the two groups were compared. Results Mean arterial pressure (MAP) and fluctuation range of hear rate after anesthesia induction (T2), at tracheal intubation (T3) and after extubation (T4) in observation group were lower than those in control group, and the difference was statistically significant (P<0.05). The visual analogue scale scores at 0.5, 1.0 and 1.5 h after regaining consciousness in observation group were lower than those in control group, and the difference was statistically significant (P<0.05). The incidence of postoperative adverse reactions of observation group was lower than that of control group, and the difference was statistically significant (P<0.05). Conclusions Add dexmedetomidine into remifentanide anesthesia for laparoscopic cholecystectomy can inhibit hyperalgesia, improve hemodynamic indicators, without increasing the incidence of adverse reactions. Key words: Laparoscopic cholecystectomy; Dexmetomidine; Remifentanil; Hyperalgesia
Published Version
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