Analgesic effect of dexmedetomidine combined with sufentanil on patients after abdominal operation under general anesthesia

Abstract

Objective To observe the analgesic effect of dexmedetomidine combined with sufentanil on patients after abdominal operation under general anesthesia. Methods 96 patients taking abdominal operation under general anesthesia were divided into an observation group and a control group, 48 cases for each group. The control group mixed sufentanil citrate 1 μg/ (kg•d), lappaconitine hydrobromide 0.01 mg/ (kg•d) and 0.6 mg ramosetron with 100 ml normal saline; the pain was stopped through venous self-control analgesic pump after the operation. The observation group mixed dexmedetomidine hydroch 1.92 μg/ (kg•d) , sufentanil citrate 0.48 μg/ (kg•d) , and 0.6 mg ramosetron with 100 ml normal saline; the pain was stopped through venous self-control analgesic pump after the operation. The pumping capacity was 1.5 ml for the first time, then the capacity was 1.5 ml/h; the analgesia period was lasted for 48 h. Results At T1, T2, T3, and T4, the VAS score and Ramesay score were obviously lower in the observation group than in the control group, with statistical differences (P 0.05). The incidence of postoperative adverse reactions was lower in the observation group than in the control group, but with no statistical difference (P>0.05). Conclusions Dexmedetomidine combined with sufentanil in abdominal operation can enhance the analgesic and sedative effect, reduce the usage of sufentanil, and decrease the incidence of adverse reactions. Key words: General anesthesia; Postoperative analgesia; Dexmedetomidine; Sufentanil