Influence of cyclic 3′, 5′-AMP on glycolysis in human erythrocytes

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Small increases in lactate production and in glucose utilization were observed when human red cells were incubated in Tris-Ringer's medium with 5 mM adenosine 3′, 5′-monophosphate (cyclic 3′, 5′-AMP) or its dibutyryl analogue. 5 mM caffeine facilitated this response whereas 5′-AMP, cyclic 2′, 3′-AMP, and guanosine 3′, 5′-AMP had no effect.