Influence of combined antihypertensive and hypolipidemic therapy on blood pressure and parameters of arterial wall stiffness in patients with hypertension

Abstract

Arterial hypertension and atherosclerosis are some of the most global problems in modern medicine. In the last decade more attention is paid to the state of central hemodynamics and arterial stiffness in patients with cardiovascular diseases, including hypertension, as one of the markers of hypertension-mediated organ damage and as a predictor of CV events. The main method of correction and tight control of blood pressure and dyslipidemia is combined antihypertensive and statin therapy. 30 patients with arterial hypertension at stage 2 and high-cardiovascular risk were involved at this study. It was detected that long-term treatment with a fixed combination of lisinopril and amlodipine in combination with rosuvastatin leads not only to normalization of blood pressure, but also to a significant decreasing of central blood pressure and a reduction in pulse wave velocity. This can act as a criterion for the organoprotective action of the combined antihypertensive and lipid lowering treatment.