Abstract
Objective To explore the influence of biphasic positive airway pressure (BiPAP) ventilation on lung function and serum cytokines in the treatment of patients with bronchial asthma. Methods 107 patients with moderate to severe bronchial asthma were divided into two groups according to the random number table method.The control group (n=54) received general supportive treatment such as expectorant, suck oxygen, balancing the water and electrolyte, anti-infection treatment.The observation group (n=53) was given BiPAP non-invasive ventilation based on the treatment of the control group.After treatment for 7 days, the clinical efficacy, improvement of lung function and serum cytokines between the two groups were compared. Results The effective rate of the observation group was 88.68%, which was higher than 72.22% of the control group, the difference was statistically significant (χ2=4.592, P=0.032). The total effective rate of the observation group was 96.23%, which was higher than 83.64% of the control group, the difference was statistically significant (χ2=4.677, P=0.031). The FEV1, FEV1/FVC, PEF levels of the observation group after treatment were (1.95±0.27)L, (65.33±6.21)%, (5.55±0.34)L/s, respectively, which were higher than those of the control group[(1.66±0.24)L, (58.24±6.09)%, (4.70±0.39)L/s], the differences were statistically significant (t=-5.872, -5.961, -12.016, all P<0.05). The serum levels of IL-4, IL-5, IL-13, IL-17, IFN-γ of the observation group after treatment were (136.77±84.63)pg/mL, (145.06±67.33)pg/mL, (12.67±4.02)ng/mL, (7.15±0.87)ng/L, (507.51±169.33)ng/L, respectively, which were lower than those of the control group[(186.95±81.36)pg/mL, (193.35±63.20)pg/mL, (14.59±3.97)ng/mL, (7.76±0.99)ng/L, (655.76±183.95)ng/L], the differences were statistically significant (t=3.136, P=0.000; t=3.832, P=0.000; t=2.497, P=0.015; t=3.389, P=0.000; t=4.341, P=0.000). Conclusion BiPAP non-invasive ventilation in the treatment of patients with moderate to severe bronchial asthma can effectively improve the lung function and reduce inflammatory cytokines, which has important reference value in clinic. Key words: Biphasic positive airway pressure; Bronchial asthma; Lung function; Cytokines
Published Version
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