Abstract
The epithelium of the female genital tract cyclically responds to ovarian hormonal function from menarche through menopause. Morphologic variations in these tissues reflect the influence of different levels of hormonal activity. Short-term administration of additional synthetic sex hormones induces abnormally high levels and target tissues in some women reveal striking histologic atypia often difficult to differentiate from carcinoma. Cervical carcinoma in situ occurs in all age groups after exposure to minimal as well as maximal ovarian hormonal stimulation. Histologic sections of this lesion from women at the extreme ends of the age range were examined and compared to determine if morphologic differences existed and were related to the variance in total ovarian hormonal stimulation. Only minor dissimilarities were observed, and these were not statistically significant in either women under 25 or over 65.
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