Effect of laparoscopic ovarian transposition on young patients undergoing radical operation of cervical cancer on ovarian endocrine function after radiotherapy

Abstract

Objective To investigate the effect of laparoscopic ovarian transposition in young patients undergoing radical operation of cervical cancer on ovarian endocrine function after radiotherapy. Methods Eighty-five young patients with cervical cancer were divided into observation group (n=45) and control group (n=40) by the random number table method. The observation group was treated by laparoscopic ovarian transposition during radical operation, while the control group was treated by bilateral oophorectomy during radical operation. Both groups received radiotherapy intervention after operation. Through detection of the levels of serum sex hormone related indexes before and after the operation, the ovarian endocrine function was compared between the two groups. Both groups were followed up for 1 year to know the status of recurrence. Ovarian function and quality of life were evaluated. Results There was no significant difference in ovarian endocrine function between the two groups before operation (P>0.05). The FSH and LH were significantly increased after operation while E2 and P were significantly decreased in the two groups(P 0.05), and postoperative Kupperman score was significantly lower than that in the control group (P<0.05). Conclusions The application of laparoscopic ovarian transposition in young patients undergoing radical operation of cervical cancer is helpful to reduce damage of endocrine function and ovarian function, reduce recurrence and improve the quality of life after radiotherapy. Key words: Young patients with cervical cancer; Radical operation of cervical cancer; Ovarian transposition; Ovarian endocrine function