Influence of a high-fat diet on inflammation and dysbiotic processes in the gums and blood serum of rats with lincomycin dysbiosis

Abstract

Background. To determine the effect on the periodontium and the whole organism of excessive consumption of palm oil, against the background of lincomycin dysbiosis.Methods.The experiments were carried out on rats, divided into 3 groups: 1st ‒ control, 2nd and 3rd with dysbiosis, which was reproduced using lincomycin administered with drinking water at a dose of 60 mg / kg for 5 days. Rats of the 3rd group additionally received palm oil at a dose of16 g / kg with food. Rats were fed for 21 days. The activity of elastase, urease, lysozyme, catalase, and the content of malondialdehyde (MDA) and hyaluronic acid were determined in the blood serum and in the gums of rats.Results. In rats, the administration of lincomycin caused an increase in the serum and gum activity of elastase and MDA content, an increase in urease activity and the degree of dysbiosis, but a significant decrease in lysozyme activity.Conclusion. The introduction of lincomycin causes the development of systemic inflammation and generalized dysbiosis, the development of gingivitis and dysbiosis in the gums, especially when combining the administration of lincomycin with the consumption of palm oil.