INFLUENCE OF A COPPER(II) COMPLEX SUPPORTED BY ACETYLACETONATES ON SURVIVAL, CYTOGENETIC PARAMETERS AND BLOOD PARAMETERS OF ANIMALS WITH III-AB DEGREE BURNS

Abstract

One of the priority tasks of modern medicine is the search for new effective means that contribute to the treatment of burn injuries. In this area, metal complexes based on copper are of particular interest. The aim of the work is to evaluate the possible beneficial effect of a Cu(II) complex supported by acetylacetonates, [Cu(acac)2], on thermal burns by determining toxicity, analyzing survival and some cytogenetic and blood parameters. The metal complex [Cu(acac)2] turned out to be a low-toxic compound: the LD50/7 value was 1815 mg/kg. The study of survival, blood counts and cytogenetic parameters showed a beneficial effect of the [Cu(acac)2]. Studies have shown that in the early stages after the burn in animals injected with [Cu(acac)2], there is a significant decrease in blood clotting time (BCT) and hematocrit, an increase in the number of leukocytes. There is also a significant decrease in the levels of platelets, erythrocytes and hemoglobin. By the end of the experiment, there was a trend towards normalization of hematological parameters. The dynamics of the survival of animals from the group "burn + injections of the metal complex" with the corresponding regression curve and an equation that allows using extrapolation to predict the change in the percentage of survival in the long term of the experiment is given. The processes of wound healing, epithelialization, hair growth in the “burn + [Cu(acac)2]” group are more intense than in the pure burn group, which indicates the beneficial effect of this metal complex on the burned organism.