Влияние металлокомплекса С10H14CuO4 на выживаемость, цитогенетические показатели и показатели крови животных с ожогами III-АВ степени

Abstract

One of the priority tasks of modern medicine is the search for new effective means that contribute to the treatment of burn injuries. In this area, organometallic complexes based on copper are of particular interest. The aim of the work is to evaluate the possible beneficial effects of the С10H14CuO4 metal complex on thermal burns by determining toxicity, analyzing survival rate and some cytogenetic and blood parameters. The С10H14CuO4 metal complex turned out to be a low-toxic compound: the LD50/7 value was 1815 mg/kg. The study of survival rate, blood values and cytogenetic parameters showed a beneficial effect of the C10H14CuO4 metal complex. Studies have shown that in the early stages after the burn and injection of the complex in animals injected with the compound C10H14CuO4, there is a significant decrease in blood clotting time and hematocrit level, an increase in the number of leukocytes. There is also a significant decrease in the levels of platelets, erythrocytes and hemoglobin. By the end of the experiment, there was a trend towards normalization of hematological parameters. The dynamics of the survival rate of animals from the group "burn + injections of the metal complex" is presented, with the corresponding regression curve and an equation that allows, by extrapolation, to predict changes in the percentage of long-term survival of the experiment. In the “burn + С10H14CuO4” group, the processes of wound healing, epithelialization, hair growth are more intense than in the pure burn group, which indicates the beneficial effect of this metal complex on the burned organism.