Effect of treatment with vitamin E and sodium selenate in some biochemical variables in the blood of male adult rats and treated with cadmium chloride

Abstract

This study designed to determine the effect of vitamine E and sodium selenite on the level of some biochemical parameters in serum of male rats exposed to oxidative stress induced by cadmium chloride. The study showed that treatment with cadmium chloride (25 mg/liter of drinking water) for 30 days caused a significant decrease in the body weight, with a significant increase in the level of glucose, cholesterol and triglycerides. Treatment of rats exposed to oxidative stress induced by cadmium chloride with vitamin E (500 mg/kg body weight) for 30 days show a non significant change in the body weight, but there was a significant increase in the level of glucose, cholesterol and triglycerides. Moreover treated rats exposed to oxidative stress induced by cadmium chloride (25 mg/liter drinking water) together with sodium selenite (0.5 mg/kg diet) for 30 days showed a non significant changes in body weight and the level of triglyceride, but a significant decrease in levels of glucose & cholesterol. Treatment with vitamin E together with sodium selenite to rats exposed to oxidative stress induced by cadmium chloride for 30 days showed a significant decrease in the level of glucose, cholesterol and triglycerides. It was concluded that administration of vitamin E with sodium selenite as antioxidants produced a significant decrease in glucose, cholesterol and triglycerides levels in rats exposed to oxidative stress induced by cadmium chloride.